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Sildenafil (sildenafil citrate) is a selective phosphodiesterase type 5 (PDE—5) inhibitor that is widely used in clinical practice for the treatment of erectile dysfunction.

Sildenafil was first synthesized in the 1980s in the laboratories of the American pharmaceutical company Pfizer. It was originally developed as a treatment for cardiovascular diseases, but during clinical trials it was found that sildenafil has a positive effect on erection. In 1996, the drug was approved for medical use under the trade name “Viagra”.

Since its introduction, sildenafil has been widely used to treat erectile dysfunction in men. It is also used in some cases of pulmonary hypertension and for the diagnosis of circulatory disorders.